Alzheimer’s disease (AD) is a complex progressive neurodegenerative disease characterized by the accumulation of Aβ plaques and tau NFTs, which are considered to result in neuronal loss, cognitive decline and dementia.
In this video, Professor Dr. Serge Gauthier explains what dementia is and what differentiates Alzheimer’s disease from other types of dementias.
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Social and physical exposome factors—like poverty, pollution, and inequality—accumulate over time, shaping biological aging and cognitive decline. Through inflammation and cellular stress, these exposures drive neurodegeneration, highlighting the need for longitudinal, integrative research.
The exposome reframes dementia as the product of cumulative physical and social exposures-like pollution, nutrition, and inequality-across life. These factors shape brain aging through inflammation and epigenetic change. Lifespan, global studies are key to equitable dementia prevention.
