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image Image Infographic showing how poor lifestyle factors and biological mechanisms like oxidative stress and inflammation contribute to neuroprogression and somatoprogression, increasing the risk of chronic diseases and mental health decline.
Shared pathways underlie disease comorbidity

Lifestyle and biological factors drive shared pathways behind neuropsychiatric and physical disease comorbidity.

22.07.2025 Depression
image Image Graphic showing extracellular, multimerization, and intracellular targets of alpha-synuclein for therapeutic intervention in Parkinson’s disease
Possible α-synuclein targets for development of therapies for Parkinson’s disease

Overview of three therapeutic strategies targeting alpha-synuclein in the development of disease-modifying treatments for Parkinson’s disease

26.06.2025 Parkinson’s Disease
image Image Chart showing progression of functional decline in Parkinson’s disease with different treatment approaches, from symptomatic benefit to disease modification.
Disease modification in Parkinson’s disease

Graphical representation of how various treatment strategies can impact disease progression in Parkinson’s disease, from symptom relief to potential cure

26.06.2025 Parkinson’s Disease
image Image Diagram showing how COMT inhibitors block the conversion of L-DOPA to 3-OMD, enhancing dopamine levels in the synapse in Parkinson’s disease.
Catechol-O-methyltransferase (COMT) inhibitors mechanism of action

Illustration of how COMT inhibitors increase dopamine availability in Parkinson’s disease by preventing the breakdown of L-DOPA

26.06.2025 Parkinson’s Disease
image Image llustration showing how MAO-B inhibitors prevent dopamine breakdown at the synapse, enhancing its availability in Parkinson’s disease
Monoamine oxidase type B (MAO-B) inhibitor mechanism of action at the synapse

Visual explanation of how MAO-B inhibitors help preserve dopamine levels in the synapse in Parkinson’s disease treatment

26.06.2025 Parkinson’s Disease
image Image Synaptic illustration showing how dopamine and dopamine agonists activate dopamine receptors in Parkinson’s disease treatment
Dopamine and dopamine agonists (DAs) at the synapse

Comparison of natural dopamine and dopamine agonists and their mechanisms of action at the synapse in Parkinson’s disease therapy.

26.06.2025 Parkinson’s Disease

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