Images

This bubble chart ranks mental disorders across Europe by estimated one year prevalence, showing anxiety disorders as the most common condition, ahead of major depression and other conditions like ADHD and personality disorders.

Sequential treatment optimization scheme for major depressive disorder generated according to international evidence.

Key steps for managing factors that may confound antidepressant treatment response, including dose, side effects, comorbidities, stressors, adherence, pharmacogenomics, interactions, and treatment algorithms.

One hypothesis of the cycle of anhedonia (loss of interest or pleasure) in patients with depression is illustrated in this image; this hypothesis comes from a series of experiments performed on a sample of psychology students.

As adjunctive treatment in MDD, some dopamine–serotonin receptor antagonists are associated with sedating side effects, while others are more often associated with ‘activating’ side effects.