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Historically, the terms young-onset and early-onset Parkinson’s disease have been used for research of Parkinson’s disease that presents before the typical age

The development of Parkinson’s Disease is generally slow and progressive

In brain-first patients (bottom panel), the dopamine system starts to degenerate early

Characteristics of proposed body-first and brain-first subtypes of Parkinson’s disease

The body-first and brain-first model suggests that the clinical subtype with mild or no “bodily symptoms” before diagnosis reflects a brain-first origin of the disease

Migraine affects an estimated 1.1 billions worldwide and ranks as the 2nd leading cause of disability, while being the leading among young adults.