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Noradrenaline binding to α2 noradrenaline receptor inhibits noradrenaline release. The α2 noradrenaline receptor is coupled to inhibitory G-proteins.

Competitive antagonists shift the dose-effect curve for an agonist, but this effect can eventually be overcome by enough agonist concentration.

Agonists are drugs that mimic the effects of endogenous neurotransmitters. Inverse agonists are drugs that have the opposite action i.e. they have opposite effects to a neurotransmitter.

Agonists are drugs that mimic the effects of endogenous neurotransmitters.

Agonists are drugs that mimic the effects of endogenous neurotransmitters. Inverse agonists are drugs that have the opposite action and opposite effects to a neurotransmitter.

Reuptake of Noradrenaline into the presynaptic neuron can be blocked by Noradrenaline reuptake Inhibitors (NRI). The binding of an NRI to the transporter prevents the reuptake of Noradrenaline.