This figure shows an overview of somatic comorbidities in schizophrenia based on nine meta-analyses encompassing ~66 million participants examined 21 distinct health outcomes.1 Thirteen outcomes demonstrated statistically significant associations with schizophrenia, indicating a substantial link between schizophrenia and multiple adverse health conditions.1
Population cohort data similarly demonstrate that schizophrenia is associated with a broadly elevated risk of most physical health conditions (hazard ratio (HR) >1).2
Adjusting for prior mental disorders attenuated some associations, but the pattern of comorbidity is consistent.1,2
The strength of supporting evidence is fragile due to heterogeneity, publication bias, and methodological variation in underlying meta-analyses.1
Data are from a nationwide population‑based cohort of 5,940,299 individuals born in Denmark between 1900 and 2015 who were residing in the country at the start of follow‑up (1 January 2000, or their first birthday thereafter). Among included individuals, 698,874 (11.8%) had received a diagnosis of a mental disorder and 5,241,425 (88.2%) had not.
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