Blood biomarkers have been developed for the key pathological processes in Alzheimer’s disease. The biomarkers develop in an overall predictable fashion during the time course of the disease, in parallel with build-up of different brain changes.

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Article cover image showing blood samples and a hand description Article
Fluid biomarkers in Alzheimer’s disease: from detecting the pathology to understanding when it causes symptoms

Advances in blood biomarkers are transforming the diagnosis and prognosis of Alzheimer’s disease, helping to assess pathology, disease progression, and co-existing pathologies.

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image Image Diagram showing current and potential applications of blood-based biomarkers across the Alzheimer’s disease pathway
Current and potential applications for fluid biomarkers

Overview of how blood-based biomarkers may support screening, diagnosis, staging, prognosis, and treatment decisions across the Alzheimer’s disease continuum.

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image Image Flowchart illustrating a plasma biomarker testing protocol for symptomatic Alzheimer’s disease
A two-step blood-based algorithm

Overview of a plasma biomarker testing pathway for symptomatic Alzheimer’s disease, using p-tau217 and eMTBR-tau243 to guide diagnostic assessment and identify underlying pathology.

13.10.2026 Alzheimer’s Disease