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There is an unmet need for PD therapies which modify the disease course

Motor complications, such dyskinesia and motor fluctuations, can greatly worsen the quality of life during mid to late PD

After years of treatment, levodopa therapy can be complicated by the development of motor complications, which include dyskinesias & motor fluctuations

The progression of Parkinson’s disease (PD) pathology occurs on a number of levels

Deaths that occur during early-stage PD are most often caused by other factors than PD itself

Multifaceted issues faced by patients with Parkinson’s disease (PD) and how genetics knowledge, using the examples of GBA1- and PRKN-related PD, can be applied clinically to aid personalized management.