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image Image Illustration of cellular mechanisms involved in GBA1 mutations and their role in Parkinson’s disease, including ER stress, lysosomal dysfunction, lipid alterations, mitochondrial dysfunction, and neuroinflammation. Created for educational use on Neurotorium.org.

Illustration of cellular mechanisms involved in GBA1 mutations and their role in Parkinson’s disease, including ER stress, lysosomal dysfunction, lipid alterations, mitochondrial dysfunction, and neuroinflammation. Created for educational use on Neurotorium.org.

GBA1 functions in the cell and Parkinson’s disease pathogenesis

The GBA1 gene plays a central role in cellular function and Parkinson’s disease pathogenesis. Explore how GBA1 mutations lead to dysfunction and neuroinflammation.

03.06.2025 Parkinson’s Disease

image Image A multi-arm, multi-stage platform trial illustration

A multi-arm, multi-stage platform trial illustration

Protocol for a multi-arm, multi-stage platform trial, whereby patients are randomly assigned to one of four sub-studies and then further randomly assigned to receive active treatment or placebo. Such a protocol determines patient selection and outcome measures, incorporating biomarkers across the different sub-studies.

29.04.2025 Alzheimer’s Disease

image Image Drug Delivery Systems to the Brain

Drug Delivery Systems to the Brain

Brain drug delivery systems, allied with their characteristics for overcoming the blood-brain barrier (BBB).

29.04.2025 Alzheimer’s Disease

image Image From One-Size-Fits-All to Precision Medicine

From One-Size-Fits-All to Precision Medicine

The use of a single treatment in heterogeneous populations has proved problematic in clinical trials undertaken in patients with neurodegenerative diseases.

29.04.2025 Alzheimer’s Disease

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