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image Image Infographic showing 20-year outcomes of positive and negative schizophrenia symptoms, including remission, relapse, and persistent symptoms
Symptom trajectories: Outcomes at 20 years’ follow-up

Positive and negative symptoms follow distinct long-term trajectories, with varying levels of remission, persistence, and relapse over 20 years.

05.08.2026 Schizophrenia
image Image Diagram showing the pathway from general population risk to clinical high risk for psychosis and transition outcomes over three years
Pathway from general population risk to psychosis: prognostic stratification in CHR‑P

From population risk to psychosis: identifying and stratifying individuals at clinical high risk

05.08.2026 Schizophrenia
image Image Flowchart showing how longer duration of untreated psychosis contributes to delayed diagnosis, worse symptoms, poorer prognosis, and reduced quality of life
The role of DUP in determining outcomes

Longer duration of untreated psychosis is associated with poorer short- and long-term clinical, functional, and quality-of-life outcomes.

05.08.2026 Schizophrenia
image Image World map showing the mean duration of untreated psychosis across countries and regions, ranging from 28 to 70 weeks
Countries and regions reporting the mean duration of untreated psychosis

The duration of untreated psychosis varies considerably across regions worldwide.

05.08.2026 Schizophrenia
image Image Line graph showing the progression of negative, positive, and cognitive symptoms across stages of schizophrenia over time
Natural course of symptoms in schizophrenia

Negative, positive, and cognitive symptoms follow distinct trajectories throughout the course of schizophrenia.

05.08.2026 Schizophrenia
image Image Timeline showing risk factors, neurobiology, and the course of schizophrenia from the perinatal period to adulthood
Risk factors, neurobiology, and course of schizophrenia

Key risk factors and neurobiological changes shape the development and progression of schizophrenia.

05.08.2026 Schizophrenia

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