Bipolar Disorder (BD) is a chronic and recurrent mood disorder affecting over 1% of the global population. In clinical settings, diagnosing BD can be difficult due to overlap of symptomology with other disorders. This slide deck introduces BD, covering key topics such as the epidemiology and burden of the disease, diagnostic criteria, differential diagnosis, and tools to support the diagnosis and assessment of BD.

This slide deck was developed by Dr. Emma Morton, PhD, Monash University, Australia, and Professor Dr. Christoph Correll, MD., The Zucker Hillside Hospital, NY, USA, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, NY, USA, Charité – Universitätsmedizin Berlin, Germany, in collaboration with Cambridge (a division of Prime, Cambridge, UK).

Index for
slide deck

Intro

History, definitions, diagnosis, epidemiology, and burden
History, definitions, diagnosis, epidemiology, and burden
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Introduction to bipolar disorder

Introduction to bipolar disorder
Introduction to bipolar disorder
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What is bipolar disorder?
What is bipolar disorder?

Bipolar disorder is a chronic and recurrent mood disorder, affecting >1% of the global population.1,6 The disorder is heritable, and commonly presents with physical and nonphysical comorbidities.1 In clinical settings, diagnosing BD can be difficult due to overlap of symp…

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The bipolar spectrum
The bipolar spectrum

One of the earliest uses of the term ‘spectrum’ in psychiatry was in 1968 for the schizophrenia spectrum.3 However, the mood spectrum comprises a range of functional psychoses, including schizophrenia and schizoaffective and affective disorders.3 Due to its dimensional na…

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The history of bipolar disorder
The history of bipolar disorder

The two extreme moods of melancholia and mania have been documented as early as the time of Hippocrates.1 In 900, Ishaq Ibn Imran wrote the monograph on melancholia, which today, is the oldest surviving manuscript dedicated to this topic.2 Up until the 19th century, melan…

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Epidemiology and burden

Epidemiology and burden
Epidemiology and burden
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The global prevalence of bipolar disorders
The global prevalence of bipolar disorders

Estimates from the WHO World Mental Health survey found that rates of comorbid disorders were significantly greater among those with bipolar I disorder (88.2%) and bipolar II disorder (83.1%), than among those with subthreshold bipolar disorder (69.1%).1

Reference:
1. Mer…

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Epidemiology
Epidemiology
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Global burden
Global burden

Bipolar disorder is associated with a high mortality rate, driven by the risk of cardiovascular disease and suicide.2 As 50% of patients initially present with a depressive episode, bipolar depression accounts for the majority of time spent unwell with the disorder, even …

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Patient impact of bipolar disorder
Patient impact of bipolar disorder

In a qualitative study, patients highlighted several aspects of the BD diagnostic process as challenging, including inadequate referral, late or incorrect diagnosis, healthcare professionals failing to recognize early warning signs, and lack of awareness within society.5

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Strengths and positive characteristics
Strengths and positive characteristics

Many patients with bipolar disorder view their illness as inherent traits of their identity, including confidence, empathy, self-awareness, social ease, productivity, and creativity.5 For patients that feel there are positive qualities to their bipolar disorder, the effec…

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